diff --git a/CMakeLists.txt b/CMakeLists.txt
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -356,20 +356,6 @@ set(CMAKE_BUILD_WITH_INSTALL_RPATH FALSE)
 # directories outside the build tree to the install RPATH
 set(CMAKE_INSTALL_RPATH_USE_LINK_PATH TRUE)
 
-# The following logic is what allows binaries to run successfully in the build
-# directory AND install directory.
-# This will need to be overridden for some targets that have a different
-# relative position to LIB_DIR using the INSTALL_RPATH target property.
-# However, we can cover the most common case for RPATH setting using the
-# global default.
-if(NOT APPLE)
-  set(CMAKE_INSTALL_RPATH "${CMAKE_INSTALL_PREFIX}/${LIB_DIR}:$ORIGIN/../${LIB_DIR}")
-else(NOT APPLE)
-  # For OSX, use the INSTALL_NAME_DIR target property
-  set(CMAKE_INSTALL_RPATH "@executable_path/../${LIB_DIR}")
-  set(CMAKE_INSTALL_NAME_DIR "@executable_path/../${LIB_DIR}")
-endif(NOT APPLE)
-
 #---------------------------------------------------------------------
 # For certain platforms (in particular Visual C++) we want to keep some pre-defined
 # flags that are commonly used in the build logic.
diff --git a/misc/CMake/BRLCAD_ExternalDeps.cmake b/misc/CMake/BRLCAD_ExternalDeps.cmake
--- a/misc/CMake/BRLCAD_ExternalDeps.cmake
+++ b/misc/CMake/BRLCAD_ExternalDeps.cmake
@@ -905,15 +905,6 @@ endfunction()
   string(REPLACE ";" "\n" TP_B "${ALL_BINARY_FILES}")
   file(WRITE "${TP_INVENTORY_BINARIES}" "${TP_B}")
 
-  if(NBINARY_FILES)
-    message("Setting rpath on new 3rd party lib and exe files...")
-    # Set local RPATH so the files will work during build
-    foreach(lf ${NBINARY_FILES})
-      rpath_build_dir_process("${CMAKE_BINARY_DIR}" "${lf}")
-    endforeach(lf ${NBINARY_FILES})
-    message("Setting rpath on new 3rd party lib and exe files... done.")
-  endif(NBINARY_FILES)
-
   if(NNOEXEC_FILES)
     message("Scrubbing paths from new 3rd party data files...")
     foreach(tf ${NNOEXEC_FILES})
diff --git a/misc/CMake/BRLCAD_Util.cmake b/misc/CMake/BRLCAD_Util.cmake
--- a/misc/CMake/BRLCAD_Util.cmake
+++ b/misc/CMake/BRLCAD_Util.cmake
@@ -220,17 +220,6 @@ function(PLUGIN_SETUP plugin_targets subdir)
       LIBRARY DESTINATION ${LIBEXEC_DIR}/${subdir}
       ARCHIVE DESTINATION ${LIBEXEC_DIR}/${subdir}
     )
-    # Set the RPATH target property
-    if(NOT APPLE)
-      set_property(
-        TARGET ${target_name}
-        PROPERTY INSTALL_RPATH "${CMAKE_INSTALL_PREFIX}/${LIB_DIR}:$ORIGIN/../../${LIB_DIR}"
-      )
-    else(NOT APPLE)
-      # For OSX, set the INSTALL_NAME_DIR target property
-      set_property(TARGET ${target_name} PROPERTY INSTALL_RPATH "@executable_path/../../${LIB_DIR}")
-      set_property(TARGET ${target_name} PROPERTY INSTALL_NAME_DIR "@executable_path/../../${LIB_DIR}")
-    endif(NOT APPLE)
   endforeach(target_name${plugins})
 endfunction(PLUGIN_SETUP)